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Giant Sand is an American rock band, based in Tucson, Arizona, USA. The name is shortened from the original Giant Sandworms, a reference to the creatures in the Dune books. Overseen by singer-songwriterHowe Gelb, its membership has shifted over the years—at times with each album. For a long while the band's rhythm section consisted of John Convertino and Joey Burns who left the band when their side project, Calexico, grew more widely known than Giant Sand and, as Gelb characterized it in 2004, Calexico "began to work against Giant Sand and eat away at what the band was".

Other members have included keyboardist Chris Cacavas (of Green on Red), bassist Paula Jean Brown (who was briefly a member of The Go-Go's and was married to Gelb at the time, drummer Tom Larkins (later to become a Jonathan Richman sideman). and Iain Shedden, drummer with Australian band The Saints.

Guest artists have included Victoria Williams, Neko Case, Juliana Hatfield, PJ Harvey, Vic Chesnutt,Steve Wynn, Vicki Peterson, Rainer Ptacek, M. Ward, Isobel Campbell nearly all members of the band Poi Dog Pondering, and regular cameos from Jello Biafra and Gelb and Brown's daughter, Indiosa Patsy Jean.